課程資訊
課程名稱
 高等化學生物學專論二
Discussion in Advanced Chemical Biology (Ⅱ) 
開課學期
 104-2 
授課對象
 理學院  化學所化學生物學組  
授課教師
 林俊宏 
課號
 Chem8036 
課程識別碼
 223ED1620 
班次
  
學分
 3 
全/半年
 半年 
必/選修
 必修 
上課時間
 星期五2,3,4(9:10~12:10) 
上課地點
  
備註
 本課程以英語授課。化學系有機組不得修習此門。TIGP-CB組必修課程。上課教室：化121。
限博士班
總人數上限：30人 
Ceiba 課程網頁
 http://ceiba.ntu.edu.tw/1042Chem8036_ 
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課程概述

This courses aim to provide students with general knowledge in the synthesis of biomolecules, which is applied either to prepare small molecules to probe target DNA/proteins, or to develop efficient methods to study biological questions. Therefore one half of the time is used to cover the synthesis, while the other half is to talk about their applications. 

課程目標
 Students who want to take the course need to pass the undergraduate course of organic chemistry (two semester courses with at least 2 hours per week). It is also recommended to have basic concept in biochemistry, at least to be aware of what are the structures of amino acids, nucleic acids and sugars. 
課程要求
 待補 
預期每週課後學習時數
  
Office Hours
  
指定閱讀
 待補 
參考書目
 待補 
評量方式
(僅供參考)
  
No.
項目
百分比
說明
1. 
 final written exam 
35% 
  
2. 
 oral presentation 
65% 
  
 
課程進度
週次
日期
單元主題
第1週
 02/26  Specific labeling of biomolecules
Hans Lin 
第2週
 03/04  Activity-based protein profiling-I
Hans Lin 
第3週
 03/11  Oligosaccharide synthesis
Todd Lowary 
第4週
 03/18  Carbohydrate-protein recognition
Todd Lowary 
第5週
 03/25  Activity-based protein profiling-II
Hans Lin 
第6週
 04/01  Introduction of expanding genetic code discovery
Yang-Shih Wang 
第7週
 04/08  Case study of protein synthesis with protein post-translational modifications and its applications
Yang-Shih Wang 
第8週
 04/15  Advance in incorporating non-canonical amino acids technology
Yang-Shih Wang 
第9週
 04/22  Natural products at a glance
Tsung-Lin Li 
第10週
 04/29  Building blocks and reactions in natural products
Tsung-Lin Li 
第11週
 05/06  Antibiotics and development
Tsung-Lin Li 
第12週
 05/13  Biosynthesis of polyketides natural products: polyketide synthases and their engineering
Hsiao-Ching Lin 
第13週
 05/20  The Biosynthesis of Natural Products: current approaches & applications (2)
Hsiao-Ching Lin 
第14週
 05/27  Natural product combinantorial biosynthesis with synthetic biology
Hsiao-Ching Lin 
第15週
 06/03  Students’ oral presentations 
第16週
 06/10  No class due to Dragon Boat Festival 
第17週
 06/17  Students’ oral presentations 
第18週
 06/24  Final Exam